Biopolymer coatings on elastomeric surfaces have significant impact for advancements in biomedicine as they combine flexible devices with complex biological functionality. Biopolymers offer increased ability for antimicrobial coatings, sensing of relevant biological markers, and controlled drug delivery. The methodologies available to conjugate these important biopolymers to flexible elastomeric substrates are vast and rapidly evolving. This chapter aims to compile methodologies across the application space of biopolymer conjugation to elastomers. We present a guide to the field and methods ranging from surface activation and functionalization, grafting-to and grafting-from of biopolymers, and characterization of the resulting substrates.