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The analysis of monocytic myeloid-derived suppressor cells (M-MDSCs) is gaining importance in the complex pathological context of neuroinflammatory diseases. M-MDSCs exert their potent immunoregulatory activity in both the central nervous system and the periphery. Since M-MDSCs lack a specific marker for their identification, the design and development of complex antibody panels for advanced confocal microscopy and flow cytometry techniques are needed to consistently and systematically detect them in both the brain and peripheral blood of human subjects.

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Detection of Monocytic Myeloid-Derived Suppressor Cells in the Human Brain and Blood

  • 实验方案

  • 发表日期：

    2025年

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  • María Cristina Ortega,
  • Virginia Vila-del Sol,
  • Isabel Machín-Díaz,
  • Diego Clemente

摘要

The analysis of monocytic myeloid-derived suppressor cells (M-MDSCs) is gaining importance in the complex pathological context of neuroinflammatory diseases. M-MDSCs exert their potent immunoregulatory activity in both the central nervous system and the periphery. Since M-MDSCs lack a specific marker for their identification, the design and development of complex antibody panels for advanced confocal microscopy and flow cytometry techniques are needed to consistently and systematically detect them in both the brain and peripheral blood of human subjects.