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A comprehensive overview is provided on how Magnetic Resonance (MR) imaging stands as a pivotal non-invasive diagnostic tool in evaluating Chronic Liver Disease (CLD). The advancement in multiparametric MR protocols offers a simultaneous, accurate, and quantitative assessment of the key pathological features of CLD: steatosis, iron content, and fibrosis. The automated organ segmentation process allows for a comprehensive and accurate evaluation of the whole liver volume, surpassing the limitations of manual regional analyses and reducing sampling errors inherent in biopsy-based assessments. This chapter details specific MR protocols including Multiecho Chemical Shift Imaging (MECSE) with Proton Density Fat Fraction (PDFF) and R2* dephasing calculations for quantification of steatosis and iron load, as well as Magnetic Resonance Elastography (MRE) for liver fibrosis assessment. The use of hepatobiliary contrast agents is also highlighted in assessing liver function, providing insights into the functional reserve and regional functionality. These MR techniques, enhanced by convolutional neural networks (CNNs) for automated whole liver segmentation, reduce variability and increase the precision of CLD assessment, facilitating better clinical decision-making and longitudinal monitoring of the disease.

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Magnetic Resonance Imaging Quantification of Steatosis, Iron, and Fibrosis in Chronic Liver Disease

  • 实验方案

  • 发表日期：

    2025年

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  • David Martí-Aguado,
  • Luis Martí-Bonmatí

摘要

A comprehensive overview is provided on how Magnetic Resonance (MR) imaging stands as a pivotal non-invasive diagnostic tool in evaluating Chronic Liver Disease (CLD). The advancement in multiparametric MR protocols offers a simultaneous, accurate, and quantitative assessment of the key pathological features of CLD: steatosis, iron content, and fibrosis. The automated organ segmentation process allows for a comprehensive and accurate evaluation of the whole liver volume, surpassing the limitations of manual regional analyses and reducing sampling errors inherent in biopsy-based assessments. This chapter details specific MR protocols including Multiecho Chemical Shift Imaging (MECSE) with Proton Density Fat Fraction (PDFF) and R2* dephasing calculations for quantification of steatosis and iron load, as well as Magnetic Resonance Elastography (MRE) for liver fibrosis assessment. The use of hepatobiliary contrast agents is also highlighted in assessing liver function, providing insights into the functional reserve and regional functionality. These MR techniques, enhanced by convolutional neural networks (CNNs) for automated whole liver segmentation, reduce variability and increase the precision of CLD assessment, facilitating better clinical decision-making and longitudinal monitoring of the disease.