Several abiotic and biotic stresses act as barriers to agricultural productivity and quality yield posing a major threat to global food security. With the world’s population increasing rapidly, there is a need to adopt sustainable and eco-friendly agricultural approaches to meet the ever-growing demand for food. Plant-associated microbiomes carry great potential to improve plant growth and resilience toward environmental constraints and pathogens. Thus, plant-microbiome engineering is an innovative strategy that has not been fully explored yet but holds great promise as an alternative approach. Out of many, the approach of designing and inoculating artificial microbial consortia (AMC) or synthetic microbial consortia in plants to achieve desired characteristics holds the immense capability to enhance plant health and reduce crop losses. It also overcomes the drawbacks associated with traditional biofertilizers like inadaptation to the local environment and incompatibility with host plants. AMC preparation consists of various steps starting with the selection of the source of microbial candidates, identification and culturing of core microorganisms, refining microbial interactions based on their compatibility, and finally assessing the consortia for their efficacy in communicating targeted benefits to the plant. Hence, studying and understanding this process will certainly help pave new ways to strengthen crop practices.