Powdered milk is a dairy product widely consumed worldwide due to its nutritional quality and ease of use. It can be stored at room temperature for extended periods without substantial loss of quality. It also finds broad application in the food industry as an ingredient in producing other dairy products, baked goods, and infant formulas. Heat application is an essential part of the powdered milk processing technology, which includes thermal treatment (pretreatment), concentration, and dehydration of fluid milk. These heat treatments significantly influence the final product’s physical and functional properties and its stability during storage. This chapter serves as a practical guide to the industrial-scale powdered milk manufacturing process, presenting the ingredients, equipment, and steps involved in its production. Additionally, it addresses how process variables influence the characteristics of the obtained product both during production and throughout its shelf life.