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Hi-C and 3C-seq are powerful tools to study the 3D genomes of bacteria and archaea, whose small cell sizes and growth conditions are often intractable to detailed microscopic analysis. However, the circularity of prokaryotic genomes requires a number of tricks for Hi-C/3C-seq data analysis. Here, I provide a practical guide to use the HiC-Pro pipeline for Hi-C/3C-seq data obtained from prokaryotes.

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Hi-C/3C-seq Data Analysis for Prokaryotic Genomes with HiC-Pro

  • 实验方案

  • 发表日期：

    2025年

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  • Naomichi Takemata

摘要

Hi-C and 3C-seq are powerful tools to study the 3D genomes of bacteria and archaea, whose small cell sizes and growth conditions are often intractable to detailed microscopic analysis. However, the circularity of prokaryotic genomes requires a number of tricks for Hi-C/3C-seq data analysis. Here, I provide a practical guide to use the HiC-Pro pipeline for Hi-C/3C-seq data obtained from prokaryotes.