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The analysis of prostaglandin urinary metabolites is valuable for assessing physiological processes and identifying disease biomarkers. These metabolites, derived from the breakdown of prostaglandins, offer a noninvasive means to gauge prostaglandin production and its potential impact on various biological functions. We report an efficient LC-MS method of four commonly analyzed prostaglandin urinary metabolites including tetranor-PGEM (derived from PGE2), tetranor-PGDM, 11β-PGF2α, and 2,3-dinor-11β-PGF2α (derived from PGD2). Each metabolite possesses distinct characteristics and clinical applications, collectively contributing to our understanding of prostaglandin-mediated pathways.

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Prostaglandin Metabolites Analysis in Urine by LC-MS/MS

  • 实验方案

  • 发表日期：

    2025年

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  • Guille Metzler,
  • Lily A. Day,
  • Richard C. King,
  • Carmen Fernández-Metzler,
  • Amitava Das,
  • T. Gregg Davis,
  • Besnik Bajrami,
  • Tom Bretschneider,
  • David Kvaskoff

摘要

The analysis of prostaglandin urinary metabolites is valuable for assessing physiological processes and identifying disease biomarkers. These metabolites, derived from the breakdown of prostaglandins, offer a noninvasive means to gauge prostaglandin production and its potential impact on various biological functions. We report an efficient LC-MS method of four commonly analyzed prostaglandin urinary metabolites including tetranor-PGEM (derived from PGE2), tetranor-PGDM, 11β-PGF2α, and 2,3-dinor-11β-PGF2α (derived from PGD2). Each metabolite possesses distinct characteristics and clinical applications, collectively contributing to our understanding of prostaglandin-mediated pathways.