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Oxidative stress induces autooxidation of polyunsaturated fatty acidsFatty acid, producing numerous isoprostanoids and isofuranoids. These oxidized products are measurable in human plasma and urine and serve as oxidative stress biomarkers for chronic diseases. This chapter details the preparation and measurement of α-linolenic acid-derived phytoprostanes and phytofurans in human samples using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS/MS).

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Nonenzymatic Oxidized Polyunsaturated Fatty Acid Products in Human Plasma and Urine Samples by LC-QTOF-MS/MS

  • 实验方案

  • 发表日期：

    2025年

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  • Kin Sum Leung,
  • Jetty Chung-Yung Lee

摘要

Oxidative stress induces autooxidation of polyunsaturated fatty acidsFatty acid, producing numerous isoprostanoids and isofuranoids. These oxidized products are measurable in human plasma and urine and serve as oxidative stress biomarkers for chronic diseases. This chapter details the preparation and measurement of α-linolenic acid-derived phytoprostanes and phytofurans in human samples using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS/MS).