GFETM: Genome Foundation-Based Embedded Topic Model for scATAC-seq Modeling
摘要
Single-cell Assay for Transposase-Accessible Chromatin with sequencing (scATAC-seq) has emerged as a powerful technique for investigating open chromatin landscapes at the single-cell level. Yet, scATAC-seq cell representation learning and its downstream tasks remain challenging due to the inherent high dimensional, sparse, and noisy properties of the data.