Stereological Evaluation of Tissue Preservation After Neuroprotective Treatments for Traumatic Spinal Cord Injury
摘要
Spinal cord injury (SCI) is a major cause of permanent disability, and its causes and pathophysiological effects are very variable between patients. The assessment of tissue damage extent and neurodegeneration degree correlated with the functional evaluation are the most accepted tools to diagnose and prognose trauma severity. Animal models of SCI have been used for treatment development. In the present work, we evaluate the power of stereological tools to estimate the damage degree for diagnosing neural degeneration and locomotor and sensorial disability after SCI as well as the efficacy of different types of therapeutic strategies.