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DNA Sizing with pg/μL Sensitivity for Cell-Free DNA Analysis with the μLAS Technology

  • Audrey Boutonnet,
  • Inga Tijunelyte,
  • Aurélien Bancaud,
  • Frédéric Ginot

摘要

The μLAS technology enables in-line DNA concentration and separation in a microchannel. Here, we describe its operation to analyze the size profile of cell-free DNA (cfDNA) extracted from bloodBlood plasma. Operated on commercial systems for capillary electrophoresis, we provide the size distribution of healthy individuals or patients using an input of 10 μL.