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Targeted Glycoproteomics Analysis Using MRM/PRM Approaches

  • Cristian D. Gutierrez Reyes,
  • Akeem Sanni,
  • Moyinoluwa Adeniyi,
  • Damir Mogut,
  • Hector R. Najera Gonzalez,
  • Parisa Ahmadi,
  • Mojgan Atashi,
  • Sherifdeen Onigbinde,
  • Yehia Mechref

摘要

MS-target analyses are frequently utilized to analyze and validate structural changes of biomolecules across diverse fields of study such as proteomics, glycoproteomics, glycomics, lipidomics, and metabolomics. Targeted studies are commonly conducted using multiple reaction monitoring (MRM) and parallel reaction monitoring (PRM) techniques. A reliable glycoproteomics analysis in intricate biological matrices is possible with these techniques, which streamline the analytical workflow, lower background interference, and enhance selectivity and specificity.