Tandem Iridium-Catalyzed C–H Borylation/Copper-Mediated Radiofluorination of Aromatic C–H Bonds with [18F]TBAF
摘要
Direct C–H functionalization of (hetero)aromatic C–H bonds with iridium-catalyzed borylation followed by copper-mediated radiofluorination of the in situ generated organoboronates affords fluorine-18 labeled aromatics in high radiochemical conversions and meta-selectivities. This protocol describes the benchtop reaction assembly of the C–H borylation and radiofluorination steps, which can be utilized for the fluorine-18 labeling of densely functionalized bioactive scaffolds.