Anti-obesity Activity of Postbiotics

Over the past few decades, metabolic problems have become more and more common. There are no effective pharmacological treatments for the majority of metabolic disorders, other than the implementation of calorie limits along with increased physical activity. Probiotics have been shown to have a variety of positive benefits on metabolism in numerous scientific studies, yet some have questioned their efficacy and safety. A recently coined term, “postbiotics,” describes a variety of bioactive molecules, including nonviable/inactivated microbial cells, cell compounds, and any soluble products or metabolic byproducts resulting from microorganisms (probiotics), which either directly or indirectly mediate beneficial biological activity when given to consumers. A dynamic relationship between the environment, hereditary sensitivity, tolerance to insulin, and pathological function of adipose tissue is accepted, given the significant increase in research and clinical emphasis over the last two decades. The physiopathology of metabolic disorders like obesity is still not fully established and is still the subject of debate. Therefore, it is imperative to emphasize that many management techniques are used to treat this disease by advocating an integrated therapy approach that places a much stronger emphasis on natural products like postbiotics. Therefore, this book chapter is an attempt to clarify the pathophysiology and effectiveness of postbiotics in obesity.