Given rapid advances in the life sciences, stem cell–based embryo models (SCBEMs) call for careful ethical and regulatory consideration. As with similar research related to human embryos and reproduction, SCBEMs raise important normative questions. In this chapter, we survey these questions, outline possible answers, and discuss their implications for global regulatory development. We also map major ethical issues related to SCBEM research, identify areas in need of further debate, and examine the governance frameworks required for responsible progress. We conclude with recommendations to guide SCBEM research so that it advances scientific innovation while protecting the public interest. In particular, we highlight the importance of careful planning, transparent communication, inclusive dialogue, robust governance, and ongoing empirical inquiry. Taken together, these measures can help ensure that SCBEM research proceeds responsibly, remains ethically sound, and earns public trust.