Scholarlink

Playing a key role in degrading RNA of the heterozygous double-strand RNA/DNA during the viral reverse transcription process, RNase H and its adjacent sites could also serve as the promising target sites for designing new anti-HIV-1 drugs to overcome the increasingly reported drug resistance effects of anti-HIV agents. While reviewing the related literatures, the structure and function of HIV-1 RNase H were introduced together with its catalytic mechanism initially, in this review. The different types of RNase H inhibitors were summarized according to their mechanism as well as structural skeletons. Contrasting and analyzing the information from these inhibitors in this review, allosteric inhibitors should be focused in order to facilitate the research process against RNase H, since there is a lot of chemical space to be explored yet in this research area.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

RNase H as the New Target for Designing Anti-HIV-1 Drugs: An Overview of Recent Research Progress

  • 章节

  • 发表日期：

    2026年

查看全文
  • Kexin Zhao,
  • Ge Meng

摘要

Playing a key role in degrading RNA of the heterozygous double-strand RNA/DNA during the viral reverse transcription process, RNase H and its adjacent sites could also serve as the promising target sites for designing new anti-HIV-1 drugs to overcome the increasingly reported drug resistance effects of anti-HIV agents. While reviewing the related literatures, the structure and function of HIV-1 RNase H were introduced together with its catalytic mechanism initially, in this review. The different types of RNase H inhibitors were summarized according to their mechanism as well as structural skeletons. Contrasting and analyzing the information from these inhibitors in this review, allosteric inhibitors should be focused in order to facilitate the research process against RNase H, since there is a lot of chemical space to be explored yet in this research area.