Multicomponent click reactions are operationally simple, short, robust, and efficient reactions that have driven the process of development of a diverse range of biologically privileged functionalized analogues. This tool has emerged as a powerful synthetic strategy enabling the rapid access of 1,2,3-triazole-appended simple-to-complex molecular architectures starting from readily available building blocks under mild reaction conditions in a one-pot fashion. This tool facilitates the simultaneous formation of multiple bonds and rationalizes the development of diverse structures including fused-ring systems, conjugates, and well-defined macrocycles. This modular approach offers exceptional selectivity and functional group compatibility in multiple CuAAC- and/or RuAAC-mediated 1,2,3-triazole-forming reactions. Our chapter highlights the notable features of multicomponent click chemistry, particularly its transformative impact on synthetic efficiency, modularity, molecular diversity, and emerging applications in medicinal chemistry, drug discovery, development of advanced functional materials for material science, and complex biomolecular assemblies for biology and medicine.