Rh-Catalyzed Functionalization of N-Heterocycles Through C–H Activation

N-heterocycles are important motifs in nature, not only because of their abundance but also because of their chemical and biological significance. In fact, approximately 70% of natural products and more than 84% of pharmaceutical drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. As a result, either synthesis or functionalization of existing nitrogen heterocycles/novel nitrogen-containing scaffolds has gained significant attention in the fields of organic and medicinal chemistry. Concurrently, a considerable amount of research has been dedicated to the development of novel nitrogen analogs and their derivatives. Particularly, this chapter focused on the Rh-catalyzed C–H functionalization/annulations of diverse synthetically valuable nitrogen heterocycles such as indoles, indolines, quinolines, isoquinolines, pyridine derivatives, etc.