Toxicity of DBPs

Human is continuously exposed to DBPs, and there is currently a large body of evidence on the health effects of DBPs in addition to the health risks from epidemiological studies. This chapter summarizes the toxic effects of DBPs in terms of in vivo, in vitro, and alternative toxicity tests. The in vivo toxicity tests detailed the carcinogenicity, reproductive and developmental toxicity, neurotoxicity, hepatotoxicity, and nephrotoxicity of DBPs, the in vitro toxicity tests reported cytotoxicity and its currently identified mechanisms, as well as genotoxicity, and the alternative toxicity tests described the toxic effects of DBPs in terms of three models, the zebrafish, the nematode, and the QSAR model. This chapter provides a comprehensive, in-depth, and systematic analysis and evaluation of the toxic effects of DBPs, which provides new approaches and insights for drinking water safety.