The objective of this chapter is to present and discuss the various aspects that are directly related to marine renewable energy development in the Greek Seas with the aim of describing the current status and identifying future potential conflicts and challenges. In order to assess the spatial context in which marine renewable energy technologies could be installed in Greece, some key factors are addressed. Specifically, the geomorphological and metocean characteristics are discussed along with the most prevalent economic activities encountered in the area of interest. The marine resource availability indicates that specific forms of marine renewable energy are favourable for exploitation in the Greek Seas based on the current technological status, while an integrated approach should be considered for the compilation of the main drivers that can activate marine renewable energy projects in the near future. Some suggestions and guidelines are also provided including policy, funding and legislation issues for the efficient exploitation of the marine resources.