Wound healing is a dynamic and complex process that consists of four interconnected phases: hemostasis, inflammation, proliferation, and remodeling. This complex process is based on the coordinated actions of growth factors, cytokines, and other cellular interactions. However, conditions such as diabetes and chronic illnesses can disrupt this process and lead to nonhealing wounds or chronic ulcers. This chapter addresses the molecular and cellular mechanisms that control both normal and impaired wound healing, with emphasis on diabetic ulcers, burns, and surgical wounds. Growth factors play a critical role in wound modulation and the potential of therapeutic interventions to restore balanced healing. Advances in tissue engineering and regenerative medicine, including hydrogel-based therapies and synthetic polymers, have produced promising solutions for wound management. In addition, 3D bioprinting offers the possibility of producing personalized skin grafts and wound dressings that closely resemble the natural skin structure. Clinical trials are currently evaluating these innovative approaches’ effectiveness and highlighting their potential to transform therapeutic outcomes in the treatment of chronic and complex wounds.