Lung cancer remains one of the leading causes of cancer-related mortality worldwide, prompting the need for innovative therapeutic strategies. Nanomaterials have emerged as a promising approach in oncology, offering enhanced targeting, improved bioavailability, and reduced side effects. This chapter explores the potential of nanomaterials derived from natural products in the treatment of lung cancer. Natural products, known for their diverse biological activities, can be effectively integrated into nanocarriers to enhance their anticancer properties. We discuss various types of nanomaterials, including nanoparticles, nanogels, and liposomes, and their ability to deliver natural compounds with anticancer effects, such as flavonoids, alkaloids, and terpenoids. Additionally, we highlight the mechanisms by which these nanomaterials facilitate targeted drug delivery, promote apoptosis in cancer cells, and overcome drug resistance. The synergy between nanotechnology and natural products represents a promising frontier in lung cancer therapy, potentially leading to more effective and personalized treatment regimens. Future directions include optimizing formulation strategies, conducting rigorous preclinical and clinical studies, and exploring the therapeutic potential of novel natural compounds in nanomaterial-based delivery systems.