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Cancer continues to pose significant challenges in treatment due to its complexity and resistance to conventional therapies. This study explores the potential of small interfering RNA (siRNA) technology for targeted cancer therapy, focusing on its ability to silence oncogenes and other crucial genes involved in tumorigenesis. However, effective delivery of siRNA remains a major hurdle. Marine peptides, derived from diverse marine organisms, offer promising solutions due to their unique biocompatibility, biodegradability, and cell-penetrating properties. This chapter highlights the synergistic potential of combining marine peptides with siRNA to enhance stability, cellular uptake, and endosomal escape, thereby improving the therapeutic efficacy of gene silencing. By leveraging the biological activities of marine peptides as carriers for siRNA, this approach aims to develop novel, targeted therapies that could significantly improve outcomes for cancer patients. The findings underscore the need for further research into peptide-siRNA complexes to revolutionize cancer treatment strategies.

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From Sea to Cell: Marine Peptides as Key Players in siRNA-Mediated Cancer Therapy

  • 章节

  • 发表日期：

    2024年

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  • Ricky Indra Alfaray,
  • Nurlinah Amalia,
  • Mochamad Fikri Ali,
  • Yehuda Tri Nugroho Supranoto,
  • Hari Darmawan,
  • Athaya Febriantyo Purnomo,
  • Adriyan Pramono,
  • Nurpudji Astuti Taslim,
  • Raymond Rubianto Tjandrawinata,
  • Trina Ekawati Tallei,
  • Fahrul Nurkolis

摘要

Cancer continues to pose significant challenges in treatment due to its complexity and resistance to conventional therapies. This study explores the potential of small interfering RNA (siRNA) technology for targeted cancer therapy, focusing on its ability to silence oncogenes and other crucial genes involved in tumorigenesis. However, effective delivery of siRNA remains a major hurdle. Marine peptides, derived from diverse marine organisms, offer promising solutions due to their unique biocompatibility, biodegradability, and cell-penetrating properties. This chapter highlights the synergistic potential of combining marine peptides with siRNA to enhance stability, cellular uptake, and endosomal escape, thereby improving the therapeutic efficacy of gene silencing. By leveraging the biological activities of marine peptides as carriers for siRNA, this approach aims to develop novel, targeted therapies that could significantly improve outcomes for cancer patients. The findings underscore the need for further research into peptide-siRNA complexes to revolutionize cancer treatment strategies.