In drug development studies, both in vivo and in vitro methods take time and have high costs. In silico methods are computer-based methods developed to save cost and time in drug development studies. In silico methods provide predictions by quickly scanning many compounds. This method is used based on the purpose of grouping, comparing, and explaining biological events. It is known that various receptors are targeted according to the cancer type in in silico methods, which are also used in cancer studies. Various drugs are used in the treatment that target various receptors that are necessary for the formation and survival of cancerous cells. Interactions with these targets are also examined in drug development studies, and a forecast report is prepared by comparing them with the interaction profiles of existing drugs. For example, estrogen receptors and progesterone receptors are prominent in breast cancer. In some cases, it may be ER+ or PR+, while in other cases both may be positive. Given these circumstances, target receptors in the development of breast cancer drugs include estrogen and progesterone receptors. In this book chapter, information about the prominent receptors in the most common cancer types from breast cancer to lung cancer, in silico methods that are prominent in cancer studies, and receptor-ligand interactions will be presented.