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Despite considerable advances in antineoplastic treatments, their adverse effects persist, negatively impacting the quality of life of patients undergoing chemotherapy and radiotherapy regimens. One of these complications is oral mucositis (OM), characterized by inflammation and ulceration of the mucosa lining the oral cavity. As this condition progresses, routine actions such as brushing teeth, eating and drinking liquids become difficult, in addition to causing a risk of systemic infections and even costs associated with maintaining and interrupting antineoplastic treatment. Therefore, the objective of this chapter is to address how photobiomodulation (PBM) can play a crucial role in the prevention and effective treatment of OM in patients undergoing cancer treatment. Initially, we will give a brief explanation about OM, followed by a comprehensive description of PBM, covering its definition, biological effects directly in the irradiated region, mechanisms of action, indications, and contraindications, including highlighting the protocols widely used for prevention and treatment, cost-effectiveness of the of PBM and precautions for head and neck cancer.

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Use of Photobiomodulation for Prevention and Treatment of Oral Mucositis Secondary to Cancer Therapies

  • 章节

  • 发表日期：

    2024年

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  • Wallacy Watson Pereira Melo,
  • Zuleni Alexandre da Silva,
  • Hadassa Helez Neves Ferreira,
  • Rafael Rodrigues Lima,
  • Renata Duarte de Souza-Rodrigues

摘要

Despite considerable advances in antineoplastic treatments, their adverse effects persist, negatively impacting the quality of life of patients undergoing chemotherapy and radiotherapy regimens. One of these complications is oral mucositis (OM), characterized by inflammation and ulceration of the mucosa lining the oral cavity. As this condition progresses, routine actions such as brushing teeth, eating and drinking liquids become difficult, in addition to causing a risk of systemic infections and even costs associated with maintaining and interrupting antineoplastic treatment. Therefore, the objective of this chapter is to address how photobiomodulation (PBM) can play a crucial role in the prevention and effective treatment of OM in patients undergoing cancer treatment. Initially, we will give a brief explanation about OM, followed by a comprehensive description of PBM, covering its definition, biological effects directly in the irradiated region, mechanisms of action, indications, and contraindications, including highlighting the protocols widely used for prevention and treatment, cost-effectiveness of the of PBM and precautions for head and neck cancer.