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Glioma is one of the most common types of primary brain tumors in adults, highly malignant and resistant to conventional treatments. Glioma-associated macrophages (GAMs) represent the major immune cell populations present in the tumor microenvironment and consist of both brain-resident microglia and monocyte-derived macrophages. Clinical studies and experimental mouse models show that tumor-reprogrammed GAMs adopt a unique phenotype of activation to support glioma growth, which in turn provides attractive targets for the development of promising immunotherapeutic strategies. Recent advances in single cell analysis techniques have allowed a definition of the heterogeneity of macrophage populations in the tissue in terms of localization and functions, overcoming the stunting issue about nomenclature and standardization of macrophage activation states.

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The Evolving Landscape of Monocyte/Macrophage System in Glioma

  • 章节

  • 发表日期：

    2023年

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  • Alessandra Maielli,
  • Federica Mornata,
  • Pasquale Persico,
  • Arianna Capucetti,
  • Raffaella Bonecchi,
  • Matteo Simonelli,
  • Massimo Locati,
  • Elena Monica Borroni,
  • Benedetta Savino

摘要

Glioma is one of the most common types of primary brain tumors in adults, highly malignant and resistant to conventional treatments. Glioma-associated macrophages (GAMs) represent the major immune cell populations present in the tumor microenvironment and consist of both brain-resident microglia and monocyte-derived macrophages. Clinical studies and experimental mouse models show that tumor-reprogrammed GAMs adopt a unique phenotype of activation to support glioma growth, which in turn provides attractive targets for the development of promising immunotherapeutic strategies. Recent advances in single cell analysis techniques have allowed a definition of the heterogeneity of macrophage populations in the tissue in terms of localization and functions, overcoming the stunting issue about nomenclature and standardization of macrophage activation states.