Despite the long history of human treatments with the electromagnetic field, the topic has numerous unclear processes. Especially only a few investigations are devoted to the immune effects of the bioelectromagnetic interactions. Our recent review collects proven pieces of evidence of the immune-supportive activity of modulated electromagnetic fields. Modulated electro-hyperthermia (mEHT) applies a synergy of thermal and nonthermal factors to select malignant cells and degrade them with the intensive cooperation of the immune system. An amplitude-modulated radiofrequency carrier induces the suitable processes to optimize apoptosis toward immunogenic cell death, considering the inherent complexity of the living organism. The immunogenic information in spatiotemporal cooperation of the produced molecules during apoptotic damage maturates the dendritic cells. The antigen-presenting cells that are formed induce innate and adaptive immune responses, developing a tumor-specific immune reaction, which degrades the malignant cells across the entire system. The mEHT process broadens the effect of the local treatment to become systemic, assisting the immune recognition of cancer cells irrespective of the size of the malignant cellular cluster, attacking the metastases and the unobservable micro-clusters of the tumor. The harmonic cooperation of the electric field and the immune processes could form the basis of a new type of researches on the subject and apply the results in human oncotherapies.