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Glioblastoma remains among the most aggressive and treatment-refractory brain tumors, prompting the exploration of alternative therapeutic strategies. Boron clusters including carboranes, metallacarboranes, and dodecaborate-based systems have gained attention as chemically versatile motifs that combine high boron density with unique biological functionality. This chapter reviews recent developments, together with selected seminal studies, in the use of boron cluster-based approaches for potential glioblastoma treatment. Strategies spanning nanostructured delivery platforms and molecularly targeted small molecules are discussed, with emphasis on structure-activity relationships, biological mechanisms, and their integration with boron neutron capture therapy.

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Boron Clusters for Potential Glioblastoma Therapy: Emerging Molecular and Nanostructured Strategies

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  • 发表日期：

    2026年

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  • Marcos Couto

摘要

Glioblastoma remains among the most aggressive and treatment-refractory brain tumors, prompting the exploration of alternative therapeutic strategies. Boron clusters including carboranes, metallacarboranes, and dodecaborate-based systems have gained attention as chemically versatile motifs that combine high boron density with unique biological functionality. This chapter reviews recent developments, together with selected seminal studies, in the use of boron cluster-based approaches for potential glioblastoma treatment. Strategies spanning nanostructured delivery platforms and molecularly targeted small molecules are discussed, with emphasis on structure-activity relationships, biological mechanisms, and their integration with boron neutron capture therapy.