<p>Machine learning and artificial intelligence are ubiquitous terms for improving technical processes. However, practical implementation in real-world problems is often difficult and complex.</p><p>This textbook explains learning methods based on analytical concepts in conjunction with complete programming examples in Python, always referring to real technical application scenarios. It demonstrates the use of physics-informed learning strategies, the incorporation of uncertainty into modeling, and the development of explainable, trustworthy artificial intelligence with the help of specialized databases.</p><p>Therefore, this textbook is aimed at students of engineering, natural science, medicine, and business administration as well as practitioners from industry (especially data scientists), developers of expert databases, and software developers.</p>