<p class="MsoNormal" style="text-align: justify; line-height: 150%;"><span lang="EN-IE" style="font-family: 'Times New Roman',serif; mso-ansi-language: EN-IE;">This open access volume describes the computational and experimental models that help researchers understand the responses of the immune system in cancer and test experimental immune-oncology approaches. The chapters in this book cover methods such as profile polarization in macrophages using ELISA; immune checkpoint inhibitors; interactions of PD-1/PD-L1 and T cells; immunocompetent preclinical mouse models to study primary and metastatic brain cancer; and methods to generate CAR T-cells. Written in the highly successful&#xa0;<em>Methods in Molecular Biology</em> series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.<br><br>Cutting-edge and comprehensive,&#xa0;<em>Immuno-Model in Cancer: Methods and Protocols&#xa0;</em>is a valuable resource for both new and experienced researchers who want to learn more about this important and developing field.</br></br></span></p><p class="MsoNormal" style="text-align: justify; line-height: 150%;"><span lang="EN-GB" style="font-family: 'Times New Roman',serif;">&#xa0;</span></p>

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IMMUNO-model in Cancer

摘要

This open access volume describes the computational and experimental models that help researchers understand the responses of the immune system in cancer and test experimental immune-oncology approaches. The chapters in this book cover methods such as profile polarization in macrophages using ELISA; immune checkpoint inhibitors; interactions of PD-1/PD-L1 and T cells; immunocompetent preclinical mouse models to study primary and metastatic brain cancer; and methods to generate CAR T-cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and comprehensive, Immuno-Model in Cancer: Methods and Protocols is a valuable resource for both new and experienced researchers who want to learn more about this important and developing field.