<p class="MsoNormal" style="margin-bottom: 0in; line-height: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif;">This second edition provides new and updated chapters on histones for molecular biologists, biochemists and geneticists. Chapters cover protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome.<span style="mso-font-kerning: 0pt;"> Written in the highly successful <em>Methods in Molecular Biology </em>series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls.</span></span></p><p class="MsoNormal" style="margin-bottom: 0in; line-height: normal;"><em><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif;">&#xa0;</span></em></p><p class="MsoNormal" style="margin-bottom: 0in; line-height: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman',serif;">Authoritative and cutting-edge, <em>Histones: Methods and Protocols, Second Edition </em>aims to be comprehensive guide for<em> </em>researchers in the field.</span></p>