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Study Objectives: <p>Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.</p> Methods: <p>OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean age 23.5 years, diabetes duration 10 years, body mass index 35.3 kg/m<sup>2</sup>). Glycated hemoglobin, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.</p> Results: <p>The prevalence of OSA in TODAY was 38.6%. OSA was not associated with glycated hemoglobin, loss of metabolic control, or diabetes-related complications in this cohort.</p> Conclusions: <p>Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.</p> <p><b>Clinical Trial Registration:</b> Registry: ClinicalTrials.gov; Name: Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY); URL: <a href="https://clinicaltrials.gov/study/NCT00081328">https://clinicaltrials.gov/study/NCT00081328</a>; Identifier: NCT00081328.</p> Citation: <p>Levitt Katz LE, El ghormli LK, Nadeau KJ, et&#xa0;al. Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study. <i>J Clin Sleep Med.</i> 2025;21(11):1925–1933.</p>

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Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Lorraine E. Levitt Katz,
  • Laure K. El ghormli,
  • Kristen J. Nadeau,
  • Amy Shah,
  • Janine Higgins,
  • Katherine Kutney,
  • Rose Gubitosi-Klug,
  • Brian Burke,
  • Babak Mokhlesi

摘要

Study Objectives:

Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.

Methods:

OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean age 23.5 years, diabetes duration 10 years, body mass index 35.3 kg/m2). Glycated hemoglobin, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.

Results:

The prevalence of OSA in TODAY was 38.6%. OSA was not associated with glycated hemoglobin, loss of metabolic control, or diabetes-related complications in this cohort.

Conclusions:

Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.

Clinical Trial Registration: Registry: ClinicalTrials.gov; Name: Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY); URL: https://clinicaltrials.gov/study/NCT00081328; Identifier: NCT00081328.

Citation:

Levitt Katz LE, El ghormli LK, Nadeau KJ, et al. Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study. J Clin Sleep Med. 2025;21(11):1925–1933.