<p>Sun et al. (<CitationRef CitationID="CR4">2025</CitationRef>) reveal the progressive, dynamic changes in the response properties of thousands of hippocampal neurons as mice learn a conditional discrimination while moving along a virtual linear track. At the end of training, separate orthogonalized ensemble codes, reflecting the properties of a state machine, capture the inherent structure of the task while dissociating the discrimination outcomes.</p>

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Emergence of orthogonal hippocampal representations during spatial learning

  • Verner P. Bingman

摘要

Sun et al. (2025) reveal the progressive, dynamic changes in the response properties of thousands of hippocampal neurons as mice learn a conditional discrimination while moving along a virtual linear track. At the end of training, separate orthogonalized ensemble codes, reflecting the properties of a state machine, capture the inherent structure of the task while dissociating the discrimination outcomes.