Voltammetric Sensor for Simultaneous Determination of 4-Aminophenol, Acetaminophen and Mefenamic Acid Based on CoFe₂O₄/MCM-41 Nanocomposite Modified Electrode

In this study, for the first time, an electrochemical sensor has been developed by synthesizing CoFe₂O₄/MCM-41 nanocomposite and incorporating it into a carbon paste matrix. The simultaneous measurement of 4-aminophenol (4-AP), acetaminophen (APAP), and mefenamic acid (MA) was performed using this sensor. Scanning electron microscopy, elemental analysis, and X-ray diffraction were used to analyze the properties of the produced nanocomposite. By using the techniques of chronoamprometry, cyclic voltammetry, impedance spectroscopy, and differential pulse voltammetry, the electrochemical behavior of the modified electrode in aqueous solutions was investigated. When compared to а bare carbon paste electrode (CPE), the peak current response of the 4-AP, APAP, and MA was significantly improved at the CoFe₂O₄/MCM-41 nanocomposite modified СРЕ (CoFe₂O₄/MCM-41/CPE). Also, using differential pulse voltammetry (DPV) method, the linear range of 4–240, 3–200 and 2–180 μM and the limit of detection (LOD) (S/N = 3.0) 1.20, 1.05 and 0.52 μM were obtained for 4-AP, APAP, and MA, respectively. The ability of CoFe₂O₄/MCM-41/CPE to detect 4-AP, APAP, and MA in waste water, tablets, urine, and tap water has been confirmed by real sample analyses results.