Hepatoprotective Effects of the Compound on Biochemical and Morphostructural Changes in Laying Hens under Thermal Stress

Various medications and feed additives having inappropriate adaptogenic and antitoxic efficacy are currently used in order to reduce the negative impact of hyperthermia on farm animals and poultry. The objective of the research study is to investigate the hepatoprotective effects of the veterinary product compound consisting of dried yeast, amorphous silicon dioxide, propylene glycol, calcium propionate, ascorbic acid, manganese, copper and zinc chelates, methionine, and choline chloride on biochemical and morphological parameter variables for laying hens under thermal stress. The stress conditions were simulated by ambient air temperature rising from 18.0 ± 1.0°C to 28.0 ± 1.0°C to expose the hens to them for 48 h. The changes in the biochemical and morphofunctional parameters for the poultry tissues and organs after hyperthermia were observed over the experiment. The serum biochemical parameter values for the control-group poultry indicated the ultimate adaptive potential for their organisms. The morphological complex change typical of protein metabolism disorders and compensatory regenerative mechanisms could prove it. Pathological changes in the structure of the duodenum, typical of catarrhal-necrotic duodenitis, were identified. In addition, the stress response affected the heart muscle, where the inflammatory process tended to progress at the underlying granular dystrophy of cardiomyocytes. The outcomes of the blood serum biochemistry tests for the experimental-group poultry indicated the intensified stress response to a thermal irritant under the effects of the studying compound (tendency to increasing the glucose and calcium contents and the alkaline phosphatase activity by 47.4%). Administering the dietary hepatoprotective compound to laying hens under the heat stress effects did not cause any disorders in the tissue and organ structures, preserving the mechanisms of cellular metabolic regulation. No pathological signs in the pattern of a complex change in the internal organs of the experimental-group poultry were recorded, indicating the active adaptive and regenerative processes.