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Abstract <p>Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.</p>

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Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • M. Divya Gnaneswari,
  • C. Raghavan,
  • L. Bruno Chandrasekar,
  • M. Karunakaran,
  • L. Saravanan,
  • S. Vimal,
  • Saravanan Rajendran,
  • Sonaimuthu Mohandoss,
  • Subramanian Palanisamy,
  • J. Thirumalai,
  • P. Shunmuga Sundaram

摘要

Abstract

Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.