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Abstract <p><b>Introduction.</b> Interindividual genetic variability primarily associated with point polymorphisms or small insertions/deletions can affect the risk of developing almost any disease in humans and their clinical course. Infectious diseases are no exception, in which the genetic characteristics of a particular person can affect both the likelihood of infection and the nature of the development of the infectious process. In recent years, special attention has been paid to studying the role of genetic factors in the formation of the clinical picture of COVID-19 caused by SARS-CoV-2 coronaviruses of modulating motor behavior impaired by the introduction of MPTP. <b>Materials and methods.</b> To carry out the typing of polymorphic DNA markers, genomic DNA was isolated from 200 μL of whole blood using a K-Sorb kit (JSC Syntol, Russia), after which genotyping was carried out by real-time PCR using TaqMan technology with SNP-Screen kits (JSC Syntol, Russia). <b>Results.</b> The possible role of polymorphic variants of the <i>IL23R, IL6, IL28B, IL17F</i> genes of the interferon systemin the development of coronavirus infection in the Russian population was analyzed. At the same time, one polymorphic variant in each gene was typed in 200 patients who had COVID-19 in 2020–2021 and were characterized by the severity of the disease. In general, all the data obtained allow us to state that the studied polymorphisms in the genes of proteins from the interferon system do not significantly affect either the likelihood of developing coronavirus infection or the severity of its clinical manifestations in patients from the Russian population. <b>Conclusions.</b> The findings allow us to state that the studied polymorphisms in the genes of proteins from the interferon system do not significantly affect either the likelihood of developing coronavirus infection or the severity of its clinical manifestations in patients from the Russian population.</p>

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Polymorphic Variants of IL23R, IL6, IL28B, IL17F Genes in Patients Who Have Survived after Coronavirus SARS-CoV-2 Infection

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. L. Klass,
  • E. V. Filatova,
  • S. B. Kalnova,
  • S. V. Rustamova,
  • M. I. Shadrina,
  • P. A. Slominsky

摘要

Abstract

Introduction. Interindividual genetic variability primarily associated with point polymorphisms or small insertions/deletions can affect the risk of developing almost any disease in humans and their clinical course. Infectious diseases are no exception, in which the genetic characteristics of a particular person can affect both the likelihood of infection and the nature of the development of the infectious process. In recent years, special attention has been paid to studying the role of genetic factors in the formation of the clinical picture of COVID-19 caused by SARS-CoV-2 coronaviruses of modulating motor behavior impaired by the introduction of MPTP. Materials and methods. To carry out the typing of polymorphic DNA markers, genomic DNA was isolated from 200 μL of whole blood using a K-Sorb kit (JSC Syntol, Russia), after which genotyping was carried out by real-time PCR using TaqMan technology with SNP-Screen kits (JSC Syntol, Russia). Results. The possible role of polymorphic variants of the IL23R, IL6, IL28B, IL17F genes of the interferon systemin the development of coronavirus infection in the Russian population was analyzed. At the same time, one polymorphic variant in each gene was typed in 200 patients who had COVID-19 in 2020–2021 and were characterized by the severity of the disease. In general, all the data obtained allow us to state that the studied polymorphisms in the genes of proteins from the interferon system do not significantly affect either the likelihood of developing coronavirus infection or the severity of its clinical manifestations in patients from the Russian population. Conclusions. The findings allow us to state that the studied polymorphisms in the genes of proteins from the interferon system do not significantly affect either the likelihood of developing coronavirus infection or the severity of its clinical manifestations in patients from the Russian population.