Scholarlink

Abstract <p><i>Phytophthora infestans</i> is a highly destructive oomycete for <i>Solanum tuberosum</i> (potato), causing&#xa0;late blight disease with significant yield losses worldwide. While resistance (R) genes and targeted editing of susceptibility (S) genes have been widely investigated for disease management, the functional dynamics of S-genes during infection are less understood. In this study, we investigated cultivar-dependent differences in late blight susceptibility and the expression of S-genes during different infection stages. <i>Desiree</i> was the most susceptible cultivar, followed by <i>Lady Rosetta</i>, <i>Sante</i>, <i>Cardinal</i>, <i>Asterix</i>, <i>Coroda</i>, and <i>Mozika</i>. While no visual tuber blight symptoms were observed, infected plants produced a significantly higher number of smaller-sized tubers, which suggests the impact of foliage late blight. Among the candidate S-genes, expression analysis revealed that <i>St-DMR6</i>, <i>St-PMR4</i>, and <i>St-CESA3</i> underwent consistent early induction (5 dpi) across all susceptible cultivars. However, by 15 dpi, expression patterns became cultivar-specific; induction was sustained in <i>Cardinal</i> and <i>Desiree</i> but suppressed in <i>Coroda</i> and <i>Lady Rosetta</i>. The early induction of S-gene(s) at 5 dpi likely depicts facilitated pathogen colonization, while sustained expression at 15 dpi indicated a stable role during later stages of infection. Our findings highlight the critical involvement of S‑genes, particularly <i>St-PMR4</i>, in mediating cultivar-specific susceptibility to <i>P. infestans</i> and provide potential targets for developing late blight-resistant potato through genome editing.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Expression Profiling of Susceptibility Genes Reveals Their Role in Cultivar-Dependent Response to Phytophthora infestans in Potato

  • 期刊论文

  • 发表日期：

    2026年6月15日

查看全文
  • Rida Khalid,
  • Muhammad Akhtar Ali,
  • Anwar Khan,
  • Bushra Tabassum

摘要

Abstract

Phytophthora infestans is a highly destructive oomycete for Solanum tuberosum (potato), causing late blight disease with significant yield losses worldwide. While resistance (R) genes and targeted editing of susceptibility (S) genes have been widely investigated for disease management, the functional dynamics of S-genes during infection are less understood. In this study, we investigated cultivar-dependent differences in late blight susceptibility and the expression of S-genes during different infection stages. Desiree was the most susceptible cultivar, followed by Lady Rosetta, Sante, Cardinal, Asterix, Coroda, and Mozika. While no visual tuber blight symptoms were observed, infected plants produced a significantly higher number of smaller-sized tubers, which suggests the impact of foliage late blight. Among the candidate S-genes, expression analysis revealed that St-DMR6, St-PMR4, and St-CESA3 underwent consistent early induction (5 dpi) across all susceptible cultivars. However, by 15 dpi, expression patterns became cultivar-specific; induction was sustained in Cardinal and Desiree but suppressed in Coroda and Lady Rosetta. The early induction of S-gene(s) at 5 dpi likely depicts facilitated pathogen colonization, while sustained expression at 15 dpi indicated a stable role during later stages of infection. Our findings highlight the critical involvement of S‑genes, particularly St-PMR4, in mediating cultivar-specific susceptibility to P. infestans and provide potential targets for developing late blight-resistant potato through genome editing.