A Comprehensive Review on Liver Regeneration Termination: A Non-Neglectable Phase

As the most important organ of detoxification in the body, the liver also has the strong regenerative ability itself. The liver can regenerate after partial hepatectomy (PH) and completely restore to its original mass. Liver regeneration (LR) has become one of research hotspots in the field of regenerative biology. Previous basic studies have predominantly concentrated on the initial and proliferative phases of regenerative response, while a relatively little attention has been paid to the mechanism of proper termination of liver regeneration. In recent years, along with the increasing recognition of the significance of LR termination, the growing researches have been carried out and some achievement has been made in a certain extent. The successful completion of LR is considered to involve many cells, growth factors, signaling pathways, metabolites and other extrahepatic factors. This article will review the progression of research on the mechanism of LR termination after PH in recent years.