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Abstract <p>Individual nanoparticles of the antibacterial drug chloramphenicol were obtained from the gas phase using the cryochemical condensation method. Carbon dioxide (СО<sub>2</sub>) was used as the carrier gas. According to the IR spectroscopic study, the chemical structure of chloramphenicol did not change during modification, however, the formation of a new polymorphic modification was possible. Hybrid chloramphenicol nanocomposites with silver nanoparticles were obtained by a similar method without the use of a carrier gas. According to the IR spectroscopy data, the chemical structure and crystalline form of chloramphenicol did not change as a result of modification but shifts in the vibrational bands of the molecular groups of chloramphenicol were observed due to the donor-acceptor interactions with the surface of dioxidine nanoparticles. According to the microscopic examination data, the size of chloramphenicol nanocomposites with silver was 112 ± 42 nm.</p>

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Cryoforming of Individual Nanoforms of Chloramphenicol and Its Hybrid Nanocomposites with Silver Nanoparticles

  • 期刊论文

  • 发表日期：

    2026年2月1日

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  • A. V. Soloviev,
  • A. K. Tomilov,
  • Yu. N. Morozov,
  • A. V. Shabatin,
  • I. V. Astashova,
  • T. I. Shabatina

摘要

Abstract

Individual nanoparticles of the antibacterial drug chloramphenicol were obtained from the gas phase using the cryochemical condensation method. Carbon dioxide (СО2) was used as the carrier gas. According to the IR spectroscopic study, the chemical structure of chloramphenicol did not change during modification, however, the formation of a new polymorphic modification was possible. Hybrid chloramphenicol nanocomposites with silver nanoparticles were obtained by a similar method without the use of a carrier gas. According to the IR spectroscopy data, the chemical structure and crystalline form of chloramphenicol did not change as a result of modification but shifts in the vibrational bands of the molecular groups of chloramphenicol were observed due to the donor-acceptor interactions with the surface of dioxidine nanoparticles. According to the microscopic examination data, the size of chloramphenicol nanocomposites with silver was 112 ± 42 nm.