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Abstract <p>In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈85 kPa) and correlated to some cosolvency and activity coefficient models. Additionally, the density of saturated mixtures was also measured and represented by the Jouyban–Acree model at various temperatures. The accuracy of each model was marked by the mean relative deviations (<i>MRD</i>%) of the back-calculated solubility and density data. The generated data in this work could be useful in the different steps of discovery and development of various formulations of AMB.</p>

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Amlodipine Besylate Solubility in Polyethylene Glycol 400 + Ethanol at Different Temperatures: Thermodynamic Analysis and Data Modeling

  • 期刊论文

  • 发表日期：

    2025年8月26日

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  • Taher Sayad,
  • Milad Moradi,
  • Parisa Jafari,
  • Elaheh Rahimpour,
  • Abolghasem Jouyban

摘要

Abstract

In the present study, the solubility values of amlodipine besylate (AMB) in the binary mixtures of polyethylene glycol 400 and ethanol were determined using the shake-flask method at 293.2 to 313.2 K under atmospheric pressure (≈85 kPa) and correlated to some cosolvency and activity coefficient models. Additionally, the density of saturated mixtures was also measured and represented by the Jouyban–Acree model at various temperatures. The accuracy of each model was marked by the mean relative deviations (MRD%) of the back-calculated solubility and density data. The generated data in this work could be useful in the different steps of discovery and development of various formulations of AMB.