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Abstract <p>This article dealt with the saturated solubility values of deferiprone (which is an iron chelator agent) in aqueous mixtures of 1-propanol using experimental measurements as well as mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with temperature and 1-propanol content. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the fitting results demonstrated that the computed solubility results from the employed computational cosolvency models were in good agreement with the experimental data. It was anticipated that these experimental solubilities, density values, and correlation results can be employed for pharmaceutical development such as purification, drug manufacturing, crystallization, and extraction on an industrial scale as well as in theoretical research.</p>

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Measurement and Correlation of Deferiprone Solubility in 1-Propanol and Water Solvent Mixtures at Different Temperatures

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Homa Rezaei,
  • Elaheh Rahimpour,
  • Fleming Martinez,
  • Abolghasem Jouyban

摘要

Abstract

This article dealt with the saturated solubility values of deferiprone (which is an iron chelator agent) in aqueous mixtures of 1-propanol using experimental measurements as well as mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with temperature and 1-propanol content. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the fitting results demonstrated that the computed solubility results from the employed computational cosolvency models were in good agreement with the experimental data. It was anticipated that these experimental solubilities, density values, and correlation results can be employed for pharmaceutical development such as purification, drug manufacturing, crystallization, and extraction on an industrial scale as well as in theoretical research.