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Seroprevalence of SARS-CoV-2 antibodies among children receiving primary care in Toronto, Ontario

  • 期刊论文

  • 发表日期：

    2024年8月21日

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  • Mary Aglipay,
  • Jeffrey C. Kwong,
  • Karen Colwill,
  • Anne-Claude Gringas,
  • Ashleigh Tuite,
  • Muhammad Mamdani,
  • Charles Keown-Stoneman,
  • Catherine Birken,
  • Jonathon Maguire,
  • Christopher Allen,
  • Laura N. Anderson,
  • Dana Arafeh,
  • Mateenah Jaleel,
  • Natricha Levy McFarlane,
  • Jessica A. Omand,
  • Imaan Bayoumi,
  • Cornelia M. Borkhoff,
  • Sarah Carsley,
  • Katherine Cost,
  • Curtis D’Hollander,
  • Anne Fuller,
  • Laura Kinlin,
  • Patricia Li,
  • Pat Parkin,
  • Nav Persaud,
  • Izabela Socynska,
  • Shelley Vanderhout,
  • Leigh Vanderloo,
  • Peter Wong,
  • Xuedi Li,
  • Michelle Mitchell,
  • Hakimat Shaibu,
  • Yulika Yoshida-Montezuma,
  • Marivic Bustos,
  • Pamela Ruth Flores,
  • Martin Ogwuru,
  • Sharon Thadani,
  • Julia Thompson,
  • Laurie Thompson,
  • Kardelen Kurt,
  • Ataat Malick,
  • Jennifer Batten,
  • Jennifer Chan,
  • John Clark,
  • Maureen Colford,
  • Amy Craig,
  • Kim De Castris-Garcia,
  • Sharon Dharman,
  • Anthony Garcia,
  • Sarah Kelleher,
  • Sandra Marquez,
  • Salimah Nasser,
  • Tammara Pabon,
  • Michelle Rhodes,
  • Rafael Salsa,
  • Jia Shin,
  • Julie Skelding,
  • Daniel Stern,
  • Kerry Stewart,
  • Erika Sendra Tavares,
  • Shannon Weir,
  • Maria Zaccaria,
  • Magdalena Janus,
  • Eric Duku,
  • Caroline Reid-Westoby,
  • Patricia Raso,
  • Amanda Offord,
  • Emy Abraham,
  • Sara Ali,
  • Kelly Anderson,
  • Gordon Arbess,
  • Jillian Baker,
  • Tony Barozzino,
  • Sylvie Bergeron,
  • Gary Bloch,
  • Joey Bonifacio,
  • Ashna Bowry,
  • Caroline Calpin,
  • Douglas Campbell,
  • Sohail Cheema,
  • Elaine Cheng,
  • Brian Chisamore,
  • Evelyn Constantin,
  • Karoon Danayan,
  • Paul Das,
  • Viveka De Guerra,
  • Mary Beth Derocher,
  • Anh Do,
  • Kathleen Doukas,
  • Anne Egger,
  • Allison Farber,
  • Amy Freedman,
  • Sloane Freeman,
  • Sharon Gazeley,
  • Karen Grewal,
  • Charlie Guiang,
  • Dan Ha,
  • Curtis Handford,
  • Laura Hanson,
  • Leah Harrington,
  • Sheila Jacobson,
  • Lukasz Jagiello,
  • Gwen Jansz,
  • Paul Kadar,
  • Lukas Keiswetter,
  • Tara Kiran,
  • Holly Knowles,
  • Bruce Kwok,
  • Piya Lahiry,
  • Sheila Lakhoo,
  • Margarita Lam-Antoniades,
  • Eddy Lau,
  • Denis Leduc,
  • Fok-Han Leung,
  • Alan Li,
  • Patricia Li,
  • Roy Male,
  • Aleks Meret,
  • Elise Mok,
  • Rosemary Moodie,
  • Katherine Nash,
  • James Owen,
  • Michael Peer,
  • Marty Perlmutar,
  • Navindra Persaud,
  • Andrew Pinto,
  • Michelle Porepa,
  • Vikky Qi,
  • Noor Ramji,
  • Danyaal Raza,
  • Katherine Rouleau,
  • Caroline Ruderman,
  • Janet Saunderson,
  • Vanna Schiralli,
  • Michael Sgro,
  • Hafiz Shuja,
  • Farah Siam,
  • Susan Shepherd,
  • Cinntha Srikanthan,
  • Carolyn Taylor,
  • Stephen Treherne,
  • Suzanne Turner,
  • Fatima Uddin,
  • Meta van den Heuvel,
  • Thea Weisdorf,
  • Peter Wong,
  • John Yaremko,
  • Ethel Ying,
  • Elizabeth Young,
  • Michael Zajdman,
  • Peter Juni,
  • Gurpreet Lakhanpal,
  • Gerald Lebovic,
  • Audra Stitt,
  • Kevin Thorpe,
  • Ifeayinchukwu (Shawn) Nnorom,
  • Esmot ara Begum,
  • Rita Kandel,
  • Michelle Rodrigues,
  • Andrea Djolovic,
  • Raya Assan,
  • Homa Bondar,
  • Geneviève Mailhot,
  • Melanie Delgado-Brand,
  • Tulunay Tursun,
  • Freda Qi,
  • Yves Durocher,
  • John Kim,
  • Anne-Claude Gingras

摘要

Objective

Characterizing the seroprevalence of SARS-CoV-2 antibodies in children is needed to optimize the COVID-19 public health response. We quantified the seroprevalence of SARS-CoV-2 infection-acquired antibodies and vaccine-acquired antibodies among children receiving primary care in Toronto, Canada.

Methods

We conducted a longitudinal cohort study between January 2021 and November 2022 in healthy children aged 0–16 years receiving primary care in Toronto. The primary and secondary outcomes were seroprevalence of SARS-COV-2 infection-acquired antibodies and vaccine-acquired antibodies ascertained from finger-prick dried blood spots. Samples were tested using an enzyme-linked immunosorbent assay for antibodies to full-length spike trimer and nucleocapsid. We explored sociodemographic differences with Firth’s penalized generalized estimating equations.

Results

Of the 475 participants, 50.1% were girls and mean age was 6.4 years (SD = 3.2). We identified 103 children seropositive for infection-acquired antibodies, with a crude seroprevalence that rose from 2.6% (95%CI 1.39–4.92) from January to July 2021 to 50.7% (95%CI 39.5–61.8) by July to November 2022. Seroprevalence of vaccine-acquired antibodies was 45.2% by July to November 2022 (95%CI 34.3–56.58). No differences in sociodemographic factors (age, sex, income, or ethnicity) were identified for infection-acquired antibodies; however, children with vaccine-acquired antibodies were more likely to be older, have mothers with university education, and have mothers who had also been vaccinated.

Conclusion

Our results provide a benchmark for seroprevalence of SARS-CoV-2 antibodies in children in Toronto. Ongoing monitoring of the serological status of children is important, particularly with the emergence of new variants of concern, low vaccine coverage, and discontinuation of PCR testing.