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<p>Minimally invasive interventional surgery techniques using guidewire-based catheters are widely adopted to treat vascular diseases. However, commonly used interventional catheters lack active guidance. The use of guidewires is associated with risks, including increased exposure to X-rays and potential vascular damage during withdrawal from complex vessels. Herein, we developed sub-millimeter microtubular ionic actuators (0.6–0.8 mm outer diameter) integrated into steerable interventional catheters. These actuators can generate large deformations (&gt;10 mm) under 7 V direct current due to enhanced ion migration, enabling precise navigation without the need for guidewires. The designed catheters achieved active bending and accurate positioning in complex arterial vascular branches within a human model. They were also able to navigate within different arterial locations (e.g., the innominate, subclavian, and carotid arteries) in pigs without the use of guidewires, and even access the ventricle and deliver contrast medium, indicating their great potential for future endovascular therapy.</p>

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Development of novel microtubular ionic actuators for endovascular navigation

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Qingsong He,
  • Siyuan Liu,
  • Xiaofang Liu,
  • Weixiang Gao,
  • Zhihao Lv,
  • Xin Shen,
  • Jinjun Duan,
  • Yunfei Han,
  • Jianfeng Zhao,
  • Ying Hu,
  • Wenqi Liu,
  • Fengjiang Zhan,
  • Longfei Chang,
  • Tao Wang,
  • Yuze Ye,
  • Qiyun Zhong,
  • Xinyu Lu,
  • Weiming Xu,
  • Yefu Wang,
  • Yang Gu,
  • Chenchu Zhang,
  • Dong Wu,
  • Yong Li

摘要

Minimally invasive interventional surgery techniques using guidewire-based catheters are widely adopted to treat vascular diseases. However, commonly used interventional catheters lack active guidance. The use of guidewires is associated with risks, including increased exposure to X-rays and potential vascular damage during withdrawal from complex vessels. Herein, we developed sub-millimeter microtubular ionic actuators (0.6–0.8 mm outer diameter) integrated into steerable interventional catheters. These actuators can generate large deformations (>10 mm) under 7 V direct current due to enhanced ion migration, enabling precise navigation without the need for guidewires. The designed catheters achieved active bending and accurate positioning in complex arterial vascular branches within a human model. They were also able to navigate within different arterial locations (e.g., the innominate, subclavian, and carotid arteries) in pigs without the use of guidewires, and even access the ventricle and deliver contrast medium, indicating their great potential for future endovascular therapy.