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<p>Chronic diabetic wounds result from a disrupted microenvironment where oxidative stress, impaired angiogenesis, and persistent infection create a vicious cycle that delays healing. Unfortunately, existing treatments often fail to address these interrelated issues, resulting in suboptimal healing. Here, we propose a base-tip dual-component hydrogel microneedle (MN) system (GBEVs-pVEGF/AgNPs@MNs), consisting of a tip loaded with plant-bacterial hybrid extracellular vesicles (GBEVs-pVEGF) and a base containing silver nanoparticles (AgNPs). Upon penetrating the necrotic tissue of diabetic wounds, our multifunctional MNs could effectively deliver GBEVs-pVEGF, thereby alleviating oxidative stress, promoting cell migration, and facilitating angiogenesis. Additionally, the physical barrier formed by the basal layer synergistically mitigates persistent bacterial infections during wound healing in conjunction with the antimicrobial agent AgNPs. This multifunctional MN system, integrating antioxidant, angiogenic, and antimicrobial properties, effectively restores the disrupted wound microenvironment, offering significant potential for accelerating diabetic wound healing.</p>

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Microneedle-loaded hybrid extracellular vesicles promote diabetic wound healing

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • Yue Sun,
  • Qirong Zhou,
  • Shihao Sheng,
  • Huijian Yang,
  • Long Bai,
  • Zhen Geng,
  • Jian Wang,
  • Ke Xu,
  • Xiao Chen,
  • Yingying Jing,
  • Guangchao Wang,
  • Jiacan Su

摘要

Chronic diabetic wounds result from a disrupted microenvironment where oxidative stress, impaired angiogenesis, and persistent infection create a vicious cycle that delays healing. Unfortunately, existing treatments often fail to address these interrelated issues, resulting in suboptimal healing. Here, we propose a base-tip dual-component hydrogel microneedle (MN) system (GBEVs-pVEGF/AgNPs@MNs), consisting of a tip loaded with plant-bacterial hybrid extracellular vesicles (GBEVs-pVEGF) and a base containing silver nanoparticles (AgNPs). Upon penetrating the necrotic tissue of diabetic wounds, our multifunctional MNs could effectively deliver GBEVs-pVEGF, thereby alleviating oxidative stress, promoting cell migration, and facilitating angiogenesis. Additionally, the physical barrier formed by the basal layer synergistically mitigates persistent bacterial infections during wound healing in conjunction with the antimicrobial agent AgNPs. This multifunctional MN system, integrating antioxidant, angiogenic, and antimicrobial properties, effectively restores the disrupted wound microenvironment, offering significant potential for accelerating diabetic wound healing.