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<p>Stem cell- or tissue-derived three-dimensional organ-like formations, known as organoids, are emerging as effective tools in biomedicine. Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols, organoids can deepen our understanding of novel disease mechanisms. In doing so, they can facilitate advancements in drug discovery platforms, pharmacological safety, and clinical trials. This review explores various biomedical applications of organoids, including drug development and disease modeling, and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments. Finally, we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.</p>

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Research insights and clinical opportunities of functional organoid-based platforms

  • 期刊论文

  • 发表日期：

    2025年11月26日

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  • Yueyu Huang,
  • Wenhui Shen,
  • Kehan Li,
  • Yutian Zhang,
  • Qiaoli Lv,
  • Changchun Wang,
  • Weimin Mao,
  • An Zhao

摘要

Stem cell- or tissue-derived three-dimensional organ-like formations, known as organoids, are emerging as effective tools in biomedicine. Since they may be useful in developing customized therapeutic solutions and efficient drug screening protocols, organoids can deepen our understanding of novel disease mechanisms. In doing so, they can facilitate advancements in drug discovery platforms, pharmacological safety, and clinical trials. This review explores various biomedical applications of organoids, including drug development and disease modeling, and highlights specific tools and analytical techniques that can be employed to investigate organoids and their microenvironments. Finally, we review recent clinical trials and patents related to organoids that show great promise for future clinical translation.