<p>This paper proposes a fatigue model of asphalt binder by quantifying the damage healing impact based on a phenomenological approach. The damage characteristic curve (DCC) obtained from the TSH test is independent of the strain amplitude, which is consistent with the pattern observed in the TS test. The average pseudo strain energy release rate (<i>G</i>^R) is found to be linearly correlated with the fatigue life (<i>N</i>_f) of asphalt binder regardless of the damage level and rest period while showing dependence on the strain amplitude. The fatigue life with healing effects increases with a longer rest period and a lower damage level. The proposed healing-considered fatigue model of asphalt binder provides reasonable <i>N</i>_f predictions, which are validated by the measured fatigue life data. Compared to the damage level and rest period, the strain amplitude has a greater impact on the fatigue law of asphalt binder.</p>