<p>The openings in the infill wall frame and the constructional columns significantly affect their mechanical properties. Accurately assessing the seismic resistance of such systems is crucial for preventing seismic damage and improving seismic design. This study established different refined finite element models to systematically analyze the seismic performance of the infill wall frame with constructional columns and half-wall openings. The impact of constructional column types, opening sizes, and masonry strength on the failure modes, skeleton curves, displacement ductility, energy dissipation characteristics, and stiffness degradation of the structures was analyzed. The results showed that cracks were evenly distributed laterally on both sides of the wall in the specimen with the prefabricated constructional column (PMSF). The peak load-bearing capacity of the specimen with PCC was about 80% of that of the specimen with the cast-in-place column (CMSF) and 110% of that of the specimen without constructional columns (MSF). The stiffness degradation rate of the PMSF specimen was slower than that of the CMSF specimen but faster than that of the MSF specimen. The equivalent viscous damping ratio of the PMSF specimen was about 75% of that of the CMSF specimen and similar to that of the MSF specimen. As the size of the opening increased, the peak load-bearing capacity and stiffness of each type of infill wall frames decreased. Higher masonry strength increased the strength and stiffness of the structure, but made it more prone to brittle failure. Finally, a simplified mechanical model of the infill wall frame structure considering the impact of constructional columns and half-wall openings was proposed. The research provides theoretical support for the engineering application of prefabricated constructional columns and has significant engineering value in improving the seismic design level of masonry infill walls and assessing the safety of existing buildings.</p>