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<p>Amorphous carbon/Fe<sub>3</sub>O<sub>4</sub> composite particles were evaluated as vectors for doxorubicin (DOX) antitumor drug delivery. DOX was loaded into a liquid solution of amorphous composite carbon and 10% Fe<sub>3</sub>O<sub>4</sub> nanoparticles to evaluate its potential as a drug carrier. The amount of DOX adsorbed was measured using UV–Vis spectroscopy to quantify the loading efficiency. The amount of DOX adsorbed by the composite reached approximately 90% in 10&#xa0;min, with little change for 20&#xa0;days. Fourier-transform infrared (FTIR) spectroscopy was used to assess the chemical functionalities present and to qualitatively examine the association of DOX with the composite after loading.</p> Graphical abstract <p></p>

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Magnetic composite amorphous carbon particles for long-term doxorubicin delivery: Adsorption and retention

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Manuel Serrano,
  • Pedro A. Márquez-Aguilar,
  • Abigail Parra-Parra,
  • Naveen Kumar Reddy Boggyreddy,
  • Yessica Calderon-Segura

摘要

Amorphous carbon/Fe3O4 composite particles were evaluated as vectors for doxorubicin (DOX) antitumor drug delivery. DOX was loaded into a liquid solution of amorphous composite carbon and 10% Fe3O4 nanoparticles to evaluate its potential as a drug carrier. The amount of DOX adsorbed was measured using UV–Vis spectroscopy to quantify the loading efficiency. The amount of DOX adsorbed by the composite reached approximately 90% in 10 min, with little change for 20 days. Fourier-transform infrared (FTIR) spectroscopy was used to assess the chemical functionalities present and to qualitatively examine the association of DOX with the composite after loading.

Graphical abstract