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<p>While graphene and graphene oxide have been extensively reported as electrode materials in various sensors, there are significant challenges standing in the way of their practical use, especially for flexible biosensors for viral RNA detection. These challenges relate to the conflicting conditions imposed by manufacturing of a GO film with uniform electronic properties, while interfacing with flexible polymeric substrates and biological recognition elements. We report on the precise manufacturing conditions for the successful development of a scalable, chemo-resistive GO electrode platform for detecting viral nucleic acids in a multi-replicate format. The as-fabricated flexible electrodes have uniform electrical resistance,1.96 ± 0.07&#xa0;kW (mean ± SD) and surface characteristics, which are necessary characteristics for high biosensing performance. We achieved a uniform graphene oxide layer after inkjet printing, precise sintering and surface treatment, and subsequent inkjet printed functionalization with ligand single-stranded DNA (ssDNA).</p> Graphical Abstract <p></p>

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Scalable manufacturing of graphene oxide electrodes for flexible nucleic acid biosensors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月15日

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  • Amit K. Barui,
  • Abbey Koneru,
  • Winston Yen-Yu Chen,
  • Ana Maria Ulloa Gomez,
  • Ya-Ching Yu,
  • Rahim Rahimi,
  • Lia A. Stanciu

摘要

While graphene and graphene oxide have been extensively reported as electrode materials in various sensors, there are significant challenges standing in the way of their practical use, especially for flexible biosensors for viral RNA detection. These challenges relate to the conflicting conditions imposed by manufacturing of a GO film with uniform electronic properties, while interfacing with flexible polymeric substrates and biological recognition elements. We report on the precise manufacturing conditions for the successful development of a scalable, chemo-resistive GO electrode platform for detecting viral nucleic acids in a multi-replicate format. The as-fabricated flexible electrodes have uniform electrical resistance,1.96 ± 0.07 kW (mean ± SD) and surface characteristics, which are necessary characteristics for high biosensing performance. We achieved a uniform graphene oxide layer after inkjet printing, precise sintering and surface treatment, and subsequent inkjet printed functionalization with ligand single-stranded DNA (ssDNA).

Graphical Abstract